Mutations at the TP53 DNA-binding domain (DBD) were found in 203 cases (175 HGSCa, 8 carcinosarcoma, 7 mucinous carcinomas, 6 endometrioid carcinoma, 3 clear cell carcinoma, 3 metastatic carcinomas, and 1 LGSCa). The gene discussed is TP53; the disease is metastatic carcinoma.