TP53 and esophageal squamous cell carcinoma: The cut-off criteria for p53 IHC staining varies across literature, mostly tumor type-dependent: there is a 5% cut-off criteria in hematologic malignancies [19]; 10% in brain tumors, esophageal squamous cell carcinoma and prostate adenocarcinoma [20,21,22,23]; 25% in oral squamous cell carcinoma [24], 40% to 50% in urothelial carcinoma [25,26], and 60% in ovarian carcinoma [27].