DLBCL, based on its gene expression profile could be classified as germinal center (GC) B-like DLBCL (GCB) and an activated B-like DLBCL (ABC), with unique gene expression signatures such as constitutive activation of nuclear factor kB (NFkB) in ABC DLBCL, and somatic mutations of polycomb repressor 2 complex gene EZH2 in GCB DLBCL [28]. Here, EZH2 is linked to diffuse large B-cell lymphoma.