Over the years, however, it was found that PRAME was not only expressed in cutaneous melanoma, but also in other types of MM including ocular, as well as in various malignant neoplasms not of melanocyte origin, such as non-small cell lung cancer [14], breast cancer [15], renal cancer [16], ovarian cancer [17], hematological malignancies [18,19,20], synovial sarcoma, and myxoid liposarcoma [21,22]. This evidence concerns the gene PRAME and Miyoshi myopathy.