Despite this, researchers have always tried to find new markers that could help, particularly in challenging cases of MM [6], such as Melan-A (MART-1) [7], HMB-45 (anti-human melanosome clone HMB45) [8], and MITF (melanocyte inducing transcription factor) [9], but the morphological difficulty together with the negativity of some histotypes of MM (such as desmoplastic melanoma) [10], has meant that even these have failed to completely resolve the diagnostic dilemmas. This evidence concerns the gene MLANA and desmoplastic melanoma.