In a 2021 paper, Jue hu et al. [38] studied the expression pattern of PRAME in acral lentiginous melanoma (LM) and acral nevi (ANs) that had never been previously analyzed; 89.3% of ALMs resulted PRAME positive, and 94.1% of ANs resulted in being completely PRAME negative. Here, PRAME is linked to acral lentiginous melanoma.