SOD1 and amyotrophic lateral sclerosis: This study provides an updated evaluation of all previously reported SOD1 variants in the Amyotrophic Lateral Sclerosis Online Genetics Database (ALSoD, https://alsod.ac.uk/, 20 December 2021), project MinE (http://databrowser.projectmine.com/, 22 December 2021) and in-house databases [18] by applying the ACMG-AMP guidelines with criteria adapted for SOD1.