In addition, Jiang et al. pointed out that the elevated lymphatic microvessel density (LMVD) stained immunohistochemically with LYVE1 antibodies had a close relationship with ventricular septal fibrosis in hypertrophic obstructive cardiomyopathy (HOCM) patients [30]. This evidence concerns the gene LYVE1 and hypertrophic cardiomyopathy.