In HARD cases, no MT-SNVs survived multiple testing correction, the most significant (nominal p < 0.05) findings (Table 2 and Figure 2) being for m.295C>T (rs41528348, p = 0.0118, MAF = 0.10, OR = 1.05; 95% CI 1.02–1.09, in control region/CR, tagging macro-haplogroup J) and m.12612A>G (rs28359172, p = 0.0158, MAF = 0.10, OR = 1.05; 95% CI 1.02–1.08, synonymous, in ND5 gene, tagging macro-haplogroup J), both more frequent in cases, thus potentially conferring increased CAD risk. This evidence concerns the gene MT-ND5 and coronary artery disorder.