EZH2 and plasma cell myeloma: In fact, somatic alterations in other chromatinopathies genes were found in myelodysplastic syndromes (ASXL1, ATRX, DNMT3A, EED, EZH2, KDM6A, KMT2 family genes, PHF6) [50], acute myeloid leukemia (ASXL1, DNMT3A, PHF6) [51], multiple myeloma (KDM6A, KMT2B, KMT2C, WHSC1) [52] and lymphoid malignancies such as acute lymphoblastic leukemia (CREBBP, DNMT3A, EP300, EED, EZH2, PHF6) and diffuse large B-cell lymphoma (CREBBP/EP300, EZH2, KMT2C/D) [52,53].