KDM1A and acute promyelocytic leukemia: Furthermore, tranylcypromine (TCP), another antidepressant, has been demonstrated to specifically inhibit LSD1, and its administration in combination with all-trans-retinoic-acid (ATRA) induces the differentiation of acute promyelocytic leukemia (APL) and acute myeloid leukemia (AML) blasts [85].