Another interesting NEDD4-1 substrate is the proapoptotic protein RTP801 (regulated in development and DNA damage responses, Redd1; DNA-damage-inducible transcript 4, DDIT4; or dexamethasone-induced gene 2 encoded protein, Dig2), a mTOR suppressor that has previously been shown to cause neuronal death in both cellular and animal models of PD [85]. This evidence concerns the gene MTOR and Parkinson disease.