α-synuclein toxicity in SH-SY5Y cells was also analysed, and it was found that the trafficking from ER (endoplasmic reticulum) to Golgi regulator (TFG), which is known to regulate ER to Golgi trafficking (a process disrupted in PD), is also an interacting protein of NEDD4-1 [72]. Here, NEDD4 is linked to Parkinson disease.