PIK3CA and metabolic epilepsy: Like other IMDs, the majority of metabolic epilepsies are inherited as autosomal recessive (497 diseases, 83% of all metabolic epilepsies), 68 diseases are autosomal dominant (11% of all metabolic epilepsies), 34 metabolic epilepsies are X-linked (6% of all metabolic epilepsies), and 1 metabolic epilepsy (catalytic phosphatidylinositol 3-kinase subunit α superactivity) is caused by a somatic mutation of PIK3CA (Supplementary Table S1).