CREB1 and Autoimmunity: It mitigates Treg cells’ immunosuppressive function through targeting the transcription factor forkhead box p3 (Foxp3) co-regulators, as well as cAMP-responsive element-binding protein1 (CREB1) and transforming growth factor B receptor 2 (TGFBR2), promoting autoimmunity [56,58].