In humans, it has been shown that 370 kinds of diseases are associated with the disruption of AS events and 2337 splicing mutations are linked to common diseases such as skipped exon 10 of microtubule associated protein tau gene (MAPT) and Alzheimer’s Disease, skipped exon 7 of fused in sarcoma/translocated in liposarcoma RNA binding protein gene (FUS) and Amyotrophic Lateral Sclerosis, and skipped exon 2 of cytotoxic T-lymphocyte associated protein 4 gene (CTLA4) and some autoimmune diseases [13,14,15,16,17]. This evidence concerns the gene CTLA4 and early-onset autosomal dominant Alzheimer disease.