GCKR and metabolic syndrome: Regional plot association analysis showed genome-wide significant associations between GCKR variants and serum total and LDL cholesterol; triglyceride, uric acid, creatinine, AST, γ-GT, albumin, and fasting plasma glucose levels; eGFR; urine albumin levels, and leukocyte and platelet counts, microalbuminuria, and metabolic syndrome (Table 3).