OPA1 and Leber hereditary optic neuropathy: In a cohort of 980 persons with suspected hereditary optic neuropathy OPA1, pathogenic variants were identified in 40% of the apparently sporadic cases (157 of 392) of optic atrophy, of which only 4% (12 cases) could be confirmed to be de novo due to the lack of parental samples in the remaining cases [1].