We observed three rare sHSP variants with MAFs less than 0.01 in the 1000G and KRGDB in the sporadic IPN patients who showed phenotypes of CMT1 or HNPP instead of CMT2 or dHMN: p.R27P and p.Q128X in HSPB1 and p.F79C in HSPB8. The gene discussed is HSPB8; the disease is bile duct papillary neoplasm.