The IPA results revealed 10 common candidate genes (CFB, CXCL2, HSD11B1, IGF1, IL6, NTN1, PCSK1, PPARGC1A, SOD2, and TF) that were inhibited in osteoporosis, sarcopenia, and diabetes but activated in obesity for all participants in the control group (Figure 4). This evidence concerns the gene CFB and obesity due to melanocortin 4 receptor deficiency.