In particular, they detected five SNVs in the first two genes/loci strongly associated with negative symptoms of schizophrenia (p-value (meta-analysis) < 0.00000622), which included three SNVs in the BCL9 gene: rs583583 showed the strongest association (p-value (meta-analysis) = 0.0000006) and two SNVs in the C9orf5 (the top SNV is rs643410, p-value = 0.00000129). This evidence concerns the gene TMEM245 and schizophrenia.