CACNB2 and major depressive disorder: A genome-wide associative study of five major psychiatric disorders showed that single-nucleotide variants (SNVs) in chromosomal loci 3p21 and 10q24, as well as the CACNA1C and CACNB2 genes encoding calcium channel subunits, are largely associated with schizophrenia, depression, bipolar disorder, attention deficit hyperactivity disorder (ADHD), and autism spectrum disorders (ASDs) [41].