Current models which demonstrate endophenotypes of both schizophrenia and depression were reviewed here, including models of CUB and SUSHI multiple domains 1, PDZ and LIM domain 5, glutamate delta 1 receptor, diabetic db/db mice, neuropeptide Y, disrupted in schizophrenia 1 and its interacting partners, reelin, maternal immune activation, and social isolation. This evidence concerns the gene RELN and depressive disorder.