The second patient was an Iranian boy who had been treated since the age of five years old for severe macrocytic anemia at Shiraz Medical University hospital (Hb 8.2 g/dL, MCV 97 fL, references Hb 11.5–14.0 g/dL, MCV 75–85 fL). This evidence concerns the gene GSTM1 and anemia (phenotype).