Downregulated DEmRs were enriched in some adipogenesis-related signaling pathways including MAPK, PI3K-Akt, Wnt, TGF-beta, insulin, Hippo, and cAMP signaling pathways, with MAPK and PI3K-Akt being the top two enriched pathways except for human papillomavirus infection whose enrichment might be associated with adenovirus infection (Figure 5D,E). Here, INS is linked to human papilloma virus infection.