The pathways were related to inflammatory reaction, including rheumatoid arthritis, prion diseases, phenylalanine metabolism, osteoclast differentiation, neuroactive ligand-receptor interaction, IL-17 signaling pathway, histidine metabolism, glycine, serine and threonine metabolism, estrogen signaling pathway, cholesterol metabolism, breast cancer, amoebiasis, and adrenergic signaling in cardiomyocytes (Figure 3D and Supplementary Table S5). The gene discussed is IL17A; the disease is prion disease.