Pathways related to metabolism activity such as, pyruvate metabolism, proximal tubule bicarbonate reclamation, propanoate metabolism, PPAR signaling pathway, peroxisome, insulin signaling pathway, insulin resistance, glycolysis/gluconeogenesis, glucagon signaling pathway, fatty acid biosynthesis, estrogen signaling pathway, endocrine resistance, AMPK signaling pathway, and adipocytokine signaling pathway were found as significantly enriched in BY_Ctl vs. BY_HS (Figure 3B and Supplementary Table S5). The gene discussed is PPARA; the disease is Insulin resistance.