We and others have suggested that HNF1A and HNF4A are involved in a regulatory network [26,59,60] and that their gene expression is tightly correlated [60,61] (Supplementary File S1, Figure S3); as such, pathogenic mutations in either the HNF1A or HNF4A gene may increase the risk of HCC by reducing their expression. Here, HNF1A is linked to hepatocellular carcinoma.