However, it has been clearly demonstrated that BRCA1-deficient breast cancers have lower levels of SIRT1 than the corresponding normal controls, and the ectopic expression of SIRT1 has been reported to inhibit BRCA1 mutant cell growth and tumor formation in a mouse model, but not in the BRCA1 wild-type [159]. The gene discussed is SIRT1; the disease is breast carcinoma.