The consequence of the abnormal placentation is reduced production and expression of angiogenic parameters, such as vascular endothelial growth factor (VEGF) and placental growth factor (PlGF), and increased placental expression and secretion of antiangiogenic factors, such as soluble fms-like tyrosine kinase 1 (sFlt-1), into maternal circulation, causing maternal systematic endothelial dysfunction. The gene discussed is PGF; the disease is endothelial dysfunction.