TIMP1 and obesity due to melanocortin 4 receptor deficiency: MMP1a mRNA and protein levels were elevated in the knee cartilage of newborn male 7-day mice in the maternal obesity group relative to those in the control group (Figure 3A, p < 0.05, Figure 3B,C, p < 0.01, respectively), while TIMP1 mRNA and protein expression levels decreased (Figure 3A, p < 0.001, Figure 3B,C, p < 0.05, respectively).