In addition, by utilizing multi-omics (transcriptomics, proteomics and neuropathological traits) integration approaches, the authors highlight a negative correlation of RNA editing in the 3′UTR of SYT11 with SYT11 protein levels, and a correlation of RNA editing at the 3′-UTR of ORAI2 with aggregation of hyperphosphorylated tau and with neuritic amyloid plaque burden, suggesting functional molecular links between RNA editing alterations and AD [55]. Here, ORAI2 is linked to Alzheimer disease.