For example, in cisplatin-sensitive glioblastoma, pediatric medulloblastoma cell lines, atypical teratoma/rhabdomyosarcoma cell lines [153], low ARHI-expressing ovarian cancer SKOV3 cells [77], p53 wild-type lung cancer H460 cells [50] and p53-null mouse breast cancer 67NR and 4T1 cells [100], CQ had no significant effect on the activity of cisplatin (Table 1). This evidence concerns the gene TP53 and ovarian carcinoma.