Surprisingly, unlike p53, a recent study suggests that the activation of RASSF1A may activate the Keap1-Nrf2 pathway by regulating microtubule-associated protein 1s (MAP1S), thus activating cytotoxicity autophagy to enhance the chemosensitivity of cisplatin in cisplatin-resistant NSCLC [105]. This evidence concerns the gene MAP1S and non-small cell lung carcinoma.