Antonioli et al. found that human papillomavirus (HPV)-negative oropharyngeal squamous cell carcinoma (OPSCC) had higher autophagy levels as well as higher AMBRA1 levels compared with HPV-positive OPSCC, while knockdown of AMBRA1 decreased cisplatin-induced cytoprotective autophagy in HPV-negative OPSCC [62]. The gene discussed is AMBRA1; the disease is oropharynx squamous cell carcinoma.