TP53 and ovarian carcinoma: A recent study showed that re-expression of p53 in p53-null SKOV3 cells increased cisplatin-induced autophagy and apoptosis in vivo and in vitro, while the induction of p53 in ERK-active Ras-expressing cells did not further induce autophagy but reversed the cisplatin resistance to sensitivity, indicating that the wild-type p53 status determines the role of autophagy in ovarian cancer chemoresistance [97].