NFE2L2 and malignant colon neoplasm: We used sulforaphane (1-isothiocyanato-4-methylsulfynbutane) (SFN), a compound derived from cruciferous vegetables, as one of the most potent inducers of NRF2 (by directly liberating NRF2 from Keap1-dependent degradation) [26] to investigate the colon cancer cell response to cisplatin (CDDP) alone or in combination with ZnCl2 supplementation.