Indeed, hyperglycemia led to the significant downregulation of mitochondrial fusion related actors, including MFN-1, MFN-2 and OPA-1 (Figure 5c), while inducing the expression of pro-fission markers namely DRP-1 and Fis-1 (p < 0.001) and confirming that overaccumulation of glucose leads to impaired mitochondria characterised by enhanced division and fission, which consequently culminate to excessive mitochondrial reactive oxygen species production. The gene discussed is FIS1; the disease is Hyperglycemia.