Nonetheless, in a mouse model for a polyglutamine disease (Dentatorubral Pallidoluysian Atrophy, DRPLA), a reduction in the nuclear level of Lamin B1 due to its cytoplasmic accumulation and excretion, correlated with nuclear degeneration (nucleophagy) and increased cell death by autophagy (Golgi-mediated-degradation, GOMED) was described [59]. Here, LMNB1 is linked to Dentatorubral pallidoluysian atrophy.