Also, the Adult-Onset-Autosomal Dominant Leukodystrophy (ADLD), a central demyelination neuropathy, is produced by a heterozygous tandem genomic duplication of the Lamin B1 gene (LMNB1), codifying for another component of the nuclear lamina. This evidence concerns the gene LMNB1 and adult-onset autosomal dominant demyelinating leukodystrophy.