Mechanistically, p53 suppresses canonical Wnt signaling through expression of miR-34, which targets several highly-conserved sites of untranslated regions in a set of Wnt pathway associated genes (CTNNB1, WNT1, LRP6, WNT3 and LEF1), and leads to the repression of TCF/LEF activity in different cancer cell lines, including breast cancer, colorectal cancer and neuroblastoma [147,148]. The gene discussed is WNT3; the disease is colorectal cancer.