MGMT and glioblastoma: Another study in glioblastoma cell lines showed that a histone deacetylase 8 inhibitor called NBM-BMX was able to downregulate Wnt/β-catenin signaling and to promote p53-mediated inhibition of the O6-methylguanine methyltransferase (MGMT) expression in glioblastoma cell lines [169].