In RN, peptidyl–tyrosine autophosphorylation, negative regulation of apoptotic and neuron apoptotic process, MAPK cascade, protein and enzyme binding, protein tyrosine kinase activity, ubiquitin protein ligase binding, cytosol, perinuclear region of cytoplasm, cytoplasm and mitochondrion were some of the over-represented GO categories; meanwhile, the neurotrophin signaling pathway, pathways in cancer and ErbB signaling pathway were some of the over-represented KEGG pathways. Here, BDNF is linked to cancer.