It must be noted that HSP90 and HSP70 together play an important roles in HSR as they can shut down HSF1 in absence of stressor (negative regulation) and also are important components of chaperone-mediated autophagy (CMA) machinery, which plays an important role in pathologies of neurodegenerative diseases, such as PD, Huntington’s disease and tauopathies, by preventing α-synuclein, polyQ-huntingtin and tau from accumulating [110,111,112,113,114]. This evidence concerns the gene HSF1 and juvenile Huntington disease.