Through a comprehensive methodology and review of the literature, we demonstrated how the HSP90 genes/proteins, which are involved in the heat shock response, regulated by HSF1 and EGFR gene/proteins, do claim a major authority over regulation and signal propagation in the PDN, along with over interactions among druggable genomes in dementia and in motif-localized hubs (the network’s stability). The gene discussed is EGFR; the disease is dementia.