ITM2B and Alzheimer disease: ProSP-C and Bri2 contain an amyloidogenic segment and it is hypothesized that BRICHOS domain prevents these segments from forming aggregates [193,194]; however, the anti-amyloidogenic properties of BRICHOS are not limited to its precursor proteins and have been extensively studied in relation to AD-associated Aβ aggregation [45,46,48,66,193,195].