The expression levels of the three experimental groups showed a downward trend, which was similar to the PC group but did not reach the level of the normal group, indicating that AMPK/ACC was activated in T2D rats after feeding with sericin; the expressions of p-AMPK, p-LKB1, p-GLUT4, GLUT4, ACC, and p-ACC were up-regulated. This evidence concerns the gene STK11 and type 2 diabetes mellitus.