The results show that all the concentrations of LS can improve the liver hyperplasia and hypertrophy caused by diabetes; at the same time, it was found that different concentrations of LS can regulate G6pase, GLK, and PCK related to the glucose metabolism pathway, and regulate the PI3K/AKT and AMPK/ACC pathways to enhance glycogen synthesis, accelerate glycolysis, and inhibit gluconeogenesis. Here, G6PC1 is linked to diabetes mellitus.