HIF1A and COVID-19: In order to verify the contribution of HIF1-α to the upregulation of proteasome subunits in COVID-19 patients, we exposed PBMCs from healthy volunteers to hypoxic conditions in combination with PX-478 (S-2-amino-3-[4V-N, N-bis (2-chloroethyl) amino]-phenyl propionic acid N-oxide dihydrochloride), which suppresses constitutive and hypoxia-induced levels of HIF1α (Figure S2A).