TUBA4A and amyotrophic lateral sclerosis: This further supports the notion that variants in the N-terminal region of TUBA4A are more likely to be associated with FTD with extrapyramidal Parkinson-like symptoms, possibly exerting its pathogenic effects through a reduction in TUBA4A, whereas variants in the C-terminal region have mainly been associated with ALS, likely disrupting the microtubule network through a dominant-negative mechanism [6].