Figure 6A shows a “three-beam” α-Syn NII (revealed with SynF1, red in overlay) that is also strongly positive for p62 (green in overlay). While this protein is classically found associated with the NCIs of α-Synucleinopathies and of various other aggregopathies [74], it is worth noting that in the nucleus, p62 condensates form a hub for proteasome-mediated protein catabolism [76]. Ubiquitination is also a classical modification found associated with NCIs in all α-Synucleinopathies [73,74,75]: Figure 6B shows a “two-beam” NII revealed with SynF1 which is also strongly positive for ubiquitin. The gene discussed is SQSTM1; the disease is synucleinopathy.