SIRT1 and hypertensive disorder: SIRT1 knockdown (SIRT1+/−) mice showed typical pre-eclampsia-like symptoms, such as hypertension, proteinuria, fetal growth restriction, kidney injury, and a narrowed placental labyrinth layer, implying that the construction of the PE-like mice model was successful, and SIRT1 heterozygote knockout is sufficient to drive the symptoms of pre-eclampsia.