Since PE can cause fetal growth restriction (FGR), we analyzed the weight of the live fetus in SIRT1flox/flox and SIRT1+/− groups, showing that the weight of the live fetus was dramatically lower in SIRT1+/− mice (Figure 2G, SIRT1+/− vs. WT: 0.7803 ± 0.1651 vs. 0.8559 ± 0.1585 g). This evidence concerns the gene SIRT1 and fetal growth restriction.