On a biological point of view, due to the ability of the adipose tissue to secrete adipokines, such as the proinflammatory leptin and the anti-inflammatory adiponectin and resistin, it may be considered an organ with endocrine functions, which may contribute to CVDs, cancer development, and prognosis (e.g., in human epidermal growth receptor 2 (HER2)-positive breast cancer) [106,107]. This evidence concerns the gene ERBB2 and cancer.