Moreover, X-linked noncoding microRNAs seem to also exert a modulatory role in the pathogenesis of cancer by interfering with ERα and ERβ expression and autophagic processes among others; more precisely, miRNA-221 and miRNA-222 impede ERα expression, which is also involved in cardiotoxicity disparities in patients undergoing chemotherapy [128]. The gene discussed is ESR1; the disease is cancer.