On the other hand, it should be noted that genomic abnormalities involving mostly the 3′UTR of PD-L1/PD-L2 (e.g., in tandem duplication, inversion, translocation, and deletions) were described in EBV-associated lymphoproliferative disorders of T and NK cells, including the extra-nodal NK T-cell lymphoma (NKTL) and the aggressive NK/T-cell leukemia. Here, CD274 is linked to extranodal nasal NK/T cell lymphoma.