In cells latently infected by the EBV showing latency types II (neoplastic cells of cHL and NPC, for instance) or III (e.g., EBV-immortalized lymphoblastoid cell lines, PTLD, and lymphomas in immunocompromised hosts), upregulation of PD-L1 can be a consequence of LMP1 expression. The gene discussed is CD274; the disease is nasopharyngeal carcinoma.