HLA-C and Epstein-Barr virus infection: The EBV infection also compromises immune responses mediated by the Major Histocompatibility Complex (MHC) molecules: for instance, the viral protein BZLF1 post-translationally downregulates CD74, involved in antigen presentation mediated by MHC class II molecules [12], while the EBV BGLF5 induces shutoff of the cellular protein synthesis machinery, affecting adversely the MHC-I-mediated recognition of infected cells by CD8+ T lymphocytes [13].