FAS and colorectal cancer: However, in another study on colorectal cancer with liver metastases, Yu et al. found that the hepatic CD11b+/F4/80+ macrophages express FasL highly when bearing liver tumors and tumor-specific T cells were siphoned into the liver in an integrin-dependent manner, subsequently leading to the activation of the extrinsic apoptosis of Fas+ T cells by the Fas–FasL pattern for promoting tumor progression [153].