By Western blotting data, Mano et al. showed that TAM-derived IL-6 can promote HCC cell proliferation by inducing STAT3 phosphorylation and S3I-201 (a STAT3 inhibitor) could decrease IL-6-induced STAT3 phosphorylation for inhibiting HCC cell proliferation [75]. Here, IL6 is linked to hepatocellular carcinoma.