Yang et al. found that endosialin expressed by cancer-associated fibroblasts (CAFs) can interact with the glycoproteins existing on the surfaces of TAM membranes, such as CD68 (the major biomarker in TAMs), inducing both the recruitment and polarization of TAMs, and this process could be inhibited by IgG78 in hepatocellular carcinoma (HCC) [42], suggesting that endosialin and CD68 might be targeted for TAMs recruitment. The gene discussed is CD68; the disease is cancer.