Meanwhile, the activation of the Akt and β-catenin signaling pathway could induce macrophage-derived soluble glycoprotein NMB (GPNMB), which could bind with the CD44 receptor and then trigger crucial survival pathways, followed by increasing the IL-33, IL-1RL1 expression, p38, STAT3, STAT5 phosphorylation, and NF-κB activation, which would ultimately promote cancer stemness [116,117]. The gene discussed is GPNMB; the disease is cancer.