IL6 and glioblastoma: For instance, in glioblastoma multiforme (GBM), Zhang et al. found that macrophage-derived IL-6 induced the phosphorylation of threonines (T243) in phosphoglycerate kinase 1 (PGK1), which was integral in GBM proliferation and the application of an anti-IL-6 antibody could abrogate this efficacy [74].