To support this, in the BC model, Liu et al. showed that bevacizumab-induced Fcγ receptor could interact with TLR4 and induce the M2b macrophages polarization; subsequently, the upregulation of indoleamine 2,3-dioxygenase 1 (IDO1) could be mediated in a TNF-α-dependent manner. The gene discussed is IDO1; the disease is breast cancer.