However, Niu et al. showed that PPARγ plays a negative role during the pro-tumorigenic polarization of TAMs in BC models, and the caspase-1 inhibitor YVAD, which inhibit the caspase-1 mediated cleavage of PPARγ, attenuated the expression of markers specific for TAM polarization [65,67]. The gene discussed is PPARG; the disease is breast cancer.