Additionally, extracellular proteins, such as endothelial growth factor (EGF), can induce M2 polarization by the activation of the EGF/PI3K/Akt/mTOR signaling pathway, and the EGFR antibody mAb225 and PI3K inhibitor LY294002 have been shown to suppress M2 polarization from monocytes in colon cancer [52,53]. Here, EGF is linked to malignant colon neoplasm.