AKT1 and breast cancer: By the establishment of the BC model, Dong et al. showed that M2 macrophage derived VEGF could enhance the expression of prostate cancer-associated transcript 6 (PCAT6) and upregulate VEGFR-2 expression simultaneously by sponging miR-4723-5p, therefore reinforcing the tumor angiogenesis through the activation of VEGFR-2/Akt/mTOR signal axis [105].