STAT6 and hereditary clear cell renal cell carcinoma: For instance, Su et al. found that blocking IL-10 by Let-7d was able to inhibit M2 polarization in renal cell carcinoma [47], and Rahal et al. found that exogenous IL-4 and IL-13 induced the phosphorylation of signal transducers and activators of transcription 6 (STAT6) and increased M2 polarization in the radioresistance of BC [48].