IL-6/STAT3 signaling has been found to be able to be mediated by integrin, a kind of membrane-spanning protein, and Kesanakurti et al. also provided findings illustrating that α5β1 integrin regulated IL-6/STAT3 signaling via interacting with matrix metallopeptidase 2 (MMP2) and Tyr1022, an α5β1 integrin inhibitor, can downregulate the activation of IL-6/STAT3 signaling and attenuate the proliferation of glioma [76], However, the targeting of the integrins of TAMs to inhibit tumor cell proliferation remains largely unexplored. Here, STAT3 is linked to central nervous system cancer.