SIRPA and acute myeloid leukemia: For instance, Majeti et al. found that cluster of differentiation 47 (CD47), a kind of “do not eat me single”, expressed on the surface of tumor cells can protect tumor cells from phagocytosis by binding to signal regulatory protein alpha (SIRPα) in TAMs and that its inhibitor (B6H12.2) could enable the phagocytosis of acute myeloid leukemia cells in a mouse model [163].