CD68 and hepatocellular carcinoma: Similarly, by transwell assay, Fan et al. showed that CD68+ TAMs mainly exhibited the M2 phenotype with a higher expression of TGF-β1, and could induce the EMT process and promote the invasive capability of HCC, while performing TGF-β1 neutralizing anti-body could attenuate TGF-β1 induced EMT, migration, and invasion of HCC [82].