VEGFA and neoplasm: Tumor vasculature is surrounded by less smooth muscle cells, sinusoidal vessel plexuses and pericytes, missing lymphatic drainage and adrenergic innervation, erratically basal membrane, and interrupted endothelial lining, it also exhibits complex branching patterns and negatively influences drug delivery [107,108,109,110,111]; therefore, the exploring of the downstream pathway after VEGF stimulation might be a promising strategy for exploiting many more targets in order to overcome the above barriers in anti-tumor therapies.