Further, Colegio et al. demonstrated that tumor-derived lactic acid promotes M2-like protumoral macrophages through HIF-1α stabilization [60]; conversely, Liu et al. and Tannahill et al. showed that glutamine-derived succinate promotes M1-like antitumoral macrophages through HIF-1α stabilization [62,63]. The gene discussed is HIF1A; the disease is neoplasm.