Among these components, collagen serves as a module of diverse signaling and is involved in the regulation of the physiological state in tumor cells [4].Recent evidence suggests that collagen type XI alpha 1 (COL11A1) is highly expressed in the invasive edge of pancreatic cancer tissues and is a novel biomarker associated with poor survival and chemoresistance in PDAC [5,6]. This evidence concerns the gene COL11A1 and pancreatic neoplasm.