A similar stimulation of NO release by desmopressin has been described in years both in vivo and in vitro, e.g., in human patients with heart failure [30], microperfused rabbit afferent arterioles [31], inner medullary collecting duct of the Brattleboro rat [32], and human umbilical vein endothelial cells (HUVEC) treated with 1 μM dDAVP after heterologous expression of V2R [33]. The gene discussed is AVPR2; the disease is heart failure.