Based on the fact that Z-AAT polymers are heterogenous and that different antibodies can recognize different profiles of polymers, we analyzed plasma samples from randomly selected ZZ AATD patients using 7.5% native PAGE following western blotting using anti-Z-polymer antibodies LG96 or 2C1 (Figure 4). The gene discussed is SERPINA1; the disease is alpha 1-antitrypsin deficiency.