Indeed, the range of plasma AAT polymers in ZZ AATD patients reported by Tan et al. [11] was 8.2–230.2 μg/mL (29- fold difference), and the range reported by Núñez [26] using the same 2C1 mAb was between 20–75 μg/mL, whereas in our assay plasma Z-AAT polymer levels had an 18-fold difference range between minimum and maximum value as shown in Figure 1. The gene discussed is SERPINA1; the disease is alpha 1-antitrypsin deficiency.