Notably, taking into account the wide range of Z-AAT polymer levels between ±100 ug/mL and ±1800 ug/mL (Figure 1), we considered that plasma levels of Z-AAT polymers were relatively stable when measured repeatedly for 14 consecutive days in these two ZZ-AATD patients (Figure 3). This evidence concerns the gene SERPINA1 and alpha 1-antitrypsin deficiency.