Investigators found that excessive alcohol intake significantly impacts PCa aggressiveness within the following genetic subgroups: CAMK2D (calcium/calmodulin-dependent protein kinase II delta, enriched in the cell cycle and the calcium signaling pathway), PRKCA (protein kinase C alpha, the modulator of cell adhesion and transformation), and ROBO1 (roundabout guidance receptor 1, cell migration factor and a tumor suppressor gene). This evidence concerns the gene CAMK2D and posterior cortical atrophy.