Inflammatory regulators involved in AD are as follows: (1) tumor necrosis factor-alpha (TNF-α), (2) interleukin (IL)-6, (3) interferon-gamma (IFN)-γ, (4) inducible protein-10 (CXCL10), (5) monocyte chemoattractant protein 1 (MCP-1), and (6) C-X-C motif ligand (CXCL-8). The gene discussed is TNF; the disease is Alzheimer disease.