A contemporary study demonstrated that statins could alleviate the cognitive deficiency of Sprague-Dawley male rats with experimental AD, lessen the stimulation of microglia and astrocytes, stall apoptosis, and downregulate TLR4, tumor necrosis factor receptor (TNFR)-associated factor 6 TRAF6 expression and mRNA/protein levels of the NF-κB pathway [217]. This evidence concerns the gene NFKB1 and Alzheimer disease.