-Induced the cytotoxicity and cell cycle perturbation in a dose-dependent manner-Induced the apoptosis of BE colorectal cancer cells-Downregulated the DNMT1 expression and the epigenetic integrator ubiquitin-like containing UHRF1-Induced an upregulation of a tumor suppressor gene: p16INK4A-Inhibited the calpain activity⇒ Targeting calpain, UHRF1,and DNMT1 using luteolin could be an interesting way to preventand/or treat colorectal cancers. The gene discussed is CDKN2A; the disease is colorectal cancer.