-Inhibited the colony formation-EGCG + quercetin inhibited viability, migration, expression of MMP-2 and -9, ALDH1 activity, colony, and spheroid formation and induced the apoptosis-EGCG + quercetin induced the expression of miR-let7-a in cancer cells⇒ EGCG and quercetin complement each other in the inhibition of PDA progression by induction of miR-let7-a and inhibition of K-ras. The gene discussed is KRAS; the disease is Patent ductus arteriosus.