-No effect on the activity of HDACs-Inhibited the DNMT activity in both SW480 and SW620 cells-Induced cell death⇒ Silibinin inhibited DNMT but not HDACactivity in colorectal SW480 and metastatic SW620 cells, and exerted synergistic effects with HDAC inhibitors on cancer cell death. Here, HDAC9 is linked to cancer.