MGMT and esophageal squamous cell carcinoma: -Reversed the CpG hypermethylation status and restored mRNA expression of the O6-methylguanine-DNA methyltransferase (MGMT) gene in ESCC⇒ DNA hypermethylation of MGMT (gene silencing in the development of ESCC), and this epigenetic event may be prevented or reversed by these polyphenols for the prevention of carcinogenesis.