In MCF-7 cells, Cur downregulated mRNA and DNMT1 protein levels and decreased the DNA methylation activity of nuclear extract [327] which was predicted for leukemia cell line in a molecular docking investigation [328,329], while the docking-based on virtual screening reported by Medina-Franco et al. [155] did not show DNA demethylation in three human cancer cell lines, which was confirmed in vitro in the study conducted by Link et al. [330] where Cur did not affect the global DNA methylation changes. This evidence concerns the gene DNMT1 and leukemia.