It has also been shown that genes involved in DNA demethylation (e.g., DNMT3A, TET2, IDH1, and IDH2) or histone methylation and demethylation (e.g., EZH2, MLL, and DOT1L) are frequently mutated in primary and secondary AML. The gene discussed is DNMT3A; the disease is acute myeloid leukemia.