EPHB2 and Familial prostate cancer: -Partial demethylation of the CpG island in the promoter of GSTP1 in all cell lines-Demethylated the CpG island of the promoter of EPHB2 in the PC-3 line-Demethylated the CpG islands of the promoter of RASSF1A in the LNCaP line-Increased the nuclear expression of GSTP1 in line DU-145-Increased the expression of EPHB2 in the nucleus of line PC-3 and the cytoplasm of DU-145 cells⇒ Epigenetic modifications of DNA,such as the promoter CpG island demethylation of tumor suppressor genes, might be related to the protective effect of genistein on prostate cancer