-Increased RECK (reversion-inducing-cysteine-rich protein with Kazal motifs) protein expression and mRNA levels-Decreased RECK promoter methylation levels (31%), global DNA methylation levels (39%), and nuclear methylation activity (71.6%)-Downregulated the mRNA levels and protein expression of DNMT1-Inhibited MGC803 cell proliferation-Reduced the DNA-binding activity of Sp1⇒ Casticin inhibits the proliferationof gastric cancer MGC803 cells by upregulating RECK gene expression and reducing intracellular methylation levels. This evidence concerns the gene RECK and gastric cancer.