-Inhibited 12-O-tetradecanoylphorbol- 13-acetate (TPA)–induced neoplastic cell transformation by 69.4 to 99.4%-Increased ARE- driven luciferase activity-Elevated mRNA and protein expression of Nrf2 downstream genes, like heme oxygenase-1 (Ho-1)-Activated the Nrf2-ARE pathway-Decreased CpG methylation in the Nrf2 promoter region-Downregulated the protein expression of DNMTs and HDACs⇒ Delphinidin can activate the Nrf2-ARE pathway, which can be applied as a potential skin cancer chemopreventive agent. The gene discussed is NFE2L2; the disease is skin cancer.