Increased the expression of RARβ at the mRNA and protein levels in tested cancer cellsDecreased the RARβ promoter methylation in lung cancer A549 and H460 cellsDownregulated the mRNA levels of DNMT3bExhibited protective effect against weight loss, because of tumor burden, in a lung cancer xenograft node mice modelRepressed the tumor growthIncreased the RARβ mRNA and decreased the DNMT3b mRNA in vitro. Here, RARB is linked to lung cancer.