Inhibited the proliferation of MPNST and primary neurofibroma cells in a dose-dependent manner.Increased the population in the G0/G1 phase but decreased in G2/M phase Reduced the expression of phosphorylated-AKT, -ERK1/2, survivin, hTERT, and acetyl H3 proteins Reduced the promoter DNA copies of survivin (BRIC5) and hTERT genesReduced the enzyme activity of HAT, but not that of HDAC. The gene discussed is AKT1; the disease is malignant peripheral nerve sheath tumor.