-Modulated the DNA methylation in bladder cancer-Inhibited the protein levels of DNMT3B without altering the expression of DNMT1 or DNMT3A-Induced a premature degradation of DNMT3B by inhibiting protein synthesis with cycloheximide (CHX)⇒ Kaempferol may promote the degradation of DNMT3B in bladder cancer. This evidence concerns the gene DNMT3A and urinary bladder cancer.