Downregulated the DNMT1 expression in AML cells in vitro and ex vivoInhibited the expression of p65 and Sp1 and their association with the DNMT1 promoterReactivated the epigenetically silenced p15INK4BIncreased the proportion of cells in SubG1 phase of the cell cycle, induced the caspase cleavage, and inhibited the AML cell growth in vitroInhibited the AML cell growth and downregulated the DNMT1 expression in vivo. Here, RELA is linked to acute myeloid leukemia.