Inhibited the cell viability and proliferation in CRC cell linesInduced the demethylation of specific CpG loci in CRC cellsNo induction of global DNA methylation changesValidated the methylation changes at several randomly selected loci including KM-HN-1, PTPRO, WT1, and GATA4Supported the DNA methylation alterations by corresponding changes in gene expression at both up- and downregulated genes in various CRC cell lines. Here, PTPRO is linked to colorectal carcinoma.