Their findings suggest that dietary polyphenols (-)-epigallocatechin-3-gallate and genistein reactivate the MGMT gene, implying that MGMT gene hypermethylation is an important mechanism for MGMT gene silencing in the development of ESCC and that this epigenetic event may be prevented or reversed by these polyphenols to prevent carcinogenesis [149]. The gene discussed is MGMT; the disease is esophageal squamous cell carcinoma.