It was reported that lung cancer-associated transcript 1 (LUCAT1) is significantly related to the development and progression of esophageal squamous cell carcinoma (ESCC) and is implicated in the regulation of DNMT1 expression and ubiquitination by UHRF1 (Ubiquitin-like with PHD and Ring Finger domains 1) an epigenetic regulator of DNMT1. The gene discussed is UHRF1; the disease is esophageal squamous cell carcinoma.