However, the enforced expression of miR-29s was shown to down-modulate expression levels of DNMT3A and -3B in lung cancer, which reduces global DNA methylation, restores expression of tumor suppressor genes such as Fragile histidine triad diadenosine triphosphatase (FHIT) and WW domain-containing oxidoreductase (WWOX), and inhibits tumorigenicity (in vitro and in vivo) [109]. This evidence concerns the gene WWOX and lung cancer.