-Reduced the BACE1 at mRNA and protein levels-Decreased the acetylated H3 in the BACE1 promoter regions through the upregulation of endogenous HDAC1-mediated deacetylation, which is independent of DNA methylation status⇒ Galangin proposes a neuroprotectivemechanism of polyphenols against alzheimer’s disease through an epigenic modifications of AD-related genes. Here, HDAC1 is linked to early-onset autosomal dominant Alzheimer disease.