-Induced the antioxidant response element (ARE) on luciferase activity in HepG2-C8 cells-Induced the expression of Nrf2 and its downstream target genes in JB6 P+ cells by CpG demethylation-Reduced the methylation level of the first 15 CpGs sites in the Nrf2 promoter-Inhibited the expression levels of DNMT and HDAC proteins⇒ Taxifolin may exhibit a skin cancer preventive effect by activating Nrf2 via anepigenetic pathway. This evidence concerns the gene NFE2L2 and skin cancer.