TP53 and neoplasm: -Inhibited the p300 acetyltransferase with competitive binding to the acetyl CoA binding site-Reduced tumor growth corresponding to a decrease in histone acetylation-Induced the cell cycle arrest-Decreased cell migration-Altered the gene expression and miRNA profile, including upregulation of p53 induced miR-195/215, let7C-Downregulated the oncomiRNAs, such as miR-135a⇒ Luteolin effects were observed at multiple levels: gene expression, miRNA expression and miRNA processing