-Inhibited viability, migration, expression of MMP-2 and -9, ALDH1 activity, colony, and spheroid formation and induced the apoptosis-Induced the expression of miR-let7-a⇒ Quercetin inhibits PDA progression by induction of miR-let7-a and inhibition of K-ras. The gene discussed is KRAS; the disease is Patent ductus arteriosus.