The efficacy of RSV on the Brca1 gene using MCF-7 breast cancer cells was confirmed by Papoutsis et al. [289] where it was shown that this compound has modulated the recruitment of AhR and ERα towards the Brca-1 promoter and antagonized the TCDD-induced histone modifications at this gene which led to an attenuation of the epigenetic changes via different mechanisms such as influencing the binding and interaction between the Brca-1 gene of various histones and enzymes. The gene discussed is ESR1; the disease is breast carcinoma.