-Increased the expression of apoptosis-related proteins and antioxidant enzymes-Inhibited the expression of DNMTs-Increased the expression and activity of ten-eleven translocation (TET) DNA demethylases-Decreased the methylation of the Nrf2 promoter region, which corresponded to the increase mRNA expression of Nrf2-Increased the TET1 binding to the Nrf2 promoter⇒ The mechanism that underlies the anticancer effects of luteolin on colon cancer involves the upregulation of Nrf2 and its interaction with the tumor suppressor. The gene discussed is NFE2L2; the disease is colonic neoplasm.