-Decreased global DNA methylation levels in A431 cells in a dose-dependent manner-Decreased the levels of DNMT activity, mRNA, and protein levels of DNMT1, DNMT3a, and DNMT3b-Decreased the HDAC activity-Increased the levels of acetylated lysine 9 and 14 on histone H3 (H3-Lys 9 and 14) and acetylated lysine 5, 12 and 16 on histone H4-Re-expressed the mRNA and proteins of silenced tumor suppressor genes, p16INK4a and Cip1/p21⇒ EGCG may contribute to the chemoprevention of skin cancer as epigenetic therapy. This evidence concerns the gene DNMT3B and skin cancer.