-Reduced the Bmi-1 and Ezh2 level in SCC-13 cells, which was associated with reduced cell survival-Reduced the histone H3 lysine 27 trimethylation-Reduced the expression of key proteins that enhance progression through the cell cycle-Increased the expression of proteins that inhibit cell cycle progression (p21 and p27)-Increased the Bax level and suppressed the Bcl-xL expression⇒ EGCG reduces skin tumor cell survival by influencing PcG-mediated epigeneticregulatory mechanisms. The gene discussed is CDKN1A; the disease is skin neoplasm.