CCND1 and liposarcoma: For instance, when DNA is damaged, the long ncRNAs associated with the cyclin D1 (CCND1) gene promoter are stimulated and they activate the function of RNA binding protein TLS (translocated in liposarcoma) that causes silencing CCND1 expression by inhibiting the HAT functions of CREB binding protein (CBP) and p300 and hence inhibit the cell cycle [117].