DNMT1 and cancer: Affected the proliferation of all four cancer cell lines in time- and dose-dependent manner after 24 hIncreased the relative expression of p21 mRNA as well as p21 protein in all four cell lines after 24 hAltered the DNMT expression and induced global DNA hypomethylationReduced the methylation specific amplification with an increase in corresponding unmethylation specific amplificationIncreased the KLF4 and p53 expressionIncreased the p21 proximal promoter occupancy by KLF4