Vardi et al. [228], on soybean phytoestrogens, aimed to determine their effect on the methylation of promoter genes (the promoter regions of glutathione S transferase P1 (GSTP1), Ras association domain family 1 (RASSF1A), ephrin B2 (EPHB2), and breast cancer 1 (BRCA1) genes) in prostate tumors. The gene discussed is RASSF1; the disease is prostate neoplasm.