RSV + PTS inhibited the growth of TNBCsRSV + PTS downregulated the SIRT1 (a type III HDAC)Res + PTS decreased the γ-H2AX and telomerase expression, which resulted in significant growth inhibition, apoptosis, and cell cycle arrest in HCC1806 and MDA-MB-157 breast cancer cellsRSV + PTS downregulated the DNMT enzymes with no significant effects on DNMT enzyme expression in MCF10A control cells. The gene discussed is H2AX; the disease is breast cancer.