RARB and breast cancer: Indeed, Lubecka et al. [174] investigated the effects of combining ClF (at IC50 concentration) with EGCG (tea catechin) or genistein (soy phytoestrogen) at physiological concentrations on breast cancer cell growth, apoptosis, and epigenetic regulation of retinoic acid receptor beta (RARB) transcriptional activity in MCF7 and MDA-MB-231 cells.