-EGCG + clofarabine synergistically:-Inhibited the growth and induced apoptosis of breast cancer cells-Induced the retinoic acid receptor beta (RARB) hypomethylation-Increased the RARB, PTEN, and CDKN1A transcript levels⇒ ClF-based combinations with EGCGpromote cancer cell death and reactivate DNA methylation-silenced tumor suppressor genes in breast cancer cells with different invasive potential. The gene discussed is CDKN1A; the disease is cancer.