The association of biochanin A with DNA hypermethylation was first reported by Fang et al. [225] in a study conducted on soy products describing how their oral administration inhibits tumorigenesis in different organs with different proposed mechanisms, they decided to study the effect of soy isoflavones and in particular of biochanin A. Biochanin A has been found to inhibit DNMT activity, reactivate RARb, and inhibit cancer cell growth. The gene discussed is RARB; the disease is cancer.