Kaempferol promoted autophagy and cell death, and increased LC3-I to LC3-II conversion and downregulation of p62 in the human GC cell lines (AGS, SNU-216, NCI-N87, SNU-638, and MKN-74) and also induced autophagic cell death via activation of IRE1-JNK-CHOP signaling, indicating an ER stress response. This evidence concerns the gene DDIT3 and gastric cancer.