ESR1 and breast cancer: -Affected the expression of oncogenic miR-221/222 and tumor suppressors (p27 and PTEN) and to estrogen receptor alpha (ERα)-Decreased the activity of DNMTs-Enriched the AcH3 within the promoter of p27 and PTEN⇒ EGCG has a role in limiting the growth andproliferation of breast cancer cells