DNMT1 and Familial prostate cancer: Restored the miR-143 and miR-145 expression in prostate cancer cell linesReduced the methylation of CpG dinucleotides in miR-143 promoterReduced the expression of DNMT1 and DNMT3BRestored the miR-143 and miR-145 expression via hypomethylationEnhanced the radiation-induced cancer cell growth inhibition and apoptosisReduced the radiation-induced autophagy in PC3 and DU145 cells