Casticin selectively reduced the viability of HCC cells but not L02 cells, repressed DNMT1 activity and expression, and increased miR-148a-3p, which indicates that the molecule activity is mediated by disrupting the reciprocal downregulation between DNMT1 and miR-148a-3p [194]. This evidence concerns the gene DNMT1 and hepatocellular carcinoma.