Cur (20 μM) + DAC (5 μM) inhibited the cancer cell colony formation, the migration through EMT (epithelial–mesenchymal transition) process regulation, the total DNMT activity, especially in DNMT3a protein expressionCur (20 μM) + DAC (5 μM) regulated the tumor suppressor gene SFRP5 expression involved in the Wnt/β-catenin signaling pathway. This evidence concerns the gene SFRP5 and cancer.