-Increased the expression of apoptosis-related proteins and antioxidant enzymes-Inhibited the expression of DNMTs-Increased the expression and activity of ten-eleven translocation (TET) DNA demethylases-Decreased the methylation of the Nrf2 promoter region, which corresponded to the increase mRNA expression of Nrf2-Increased the TET1 binding to the Nrf2 promoter⇒ The mechanism that underlies the anticancer effects of luteolin on colon cancer involves the upregulation of Nrf2 and its interaction with the tumor suppressor. Here, TET1 is linked to malignant colon neoplasm.