PTEN and neoplasm: Decreased the levels of several oncogenic microRNAs targeting genes encoding Dicer1, a cytoplasmic RNase III producing mature microRNAs from their immediate precursors, tumor-suppressor factors such as PDCD4 or PTEN, as well as key effectors of the TGFβ signaling pathwayIncreased the levels of miR-663, a tumor-suppressor microRNA targeting TGFβ1 transcriptsDecreased the transcriptional activity of SMADs, the main effectors of the canonical TGFβ pathway