Inhibited the proliferation of MPNST and primary neurofibroma cells in a dose-dependent manner.Increased the population in the G0/G1 phase but decreased in G2/M phase Reduced the expression of phosphorylated-AKT, -ERK1/2, survivin, hTERT, and acetyl H3 proteins Reduced the promoter DNA copies of survivin (BRIC5) and hTERT genesReduced the enzyme activity of HAT, but not that of HDAC. Here, MAPK3 is linked to malignant peripheral nerve sheath tumor.