-Downregulated the miR-124-3p expression in glioma tissues-Decreased cell viability and triggered apoptosis in both glioma cell lines in a dose-dependent manner-Induced the apoptosis and inhibited glycolysis in the glioma cells by upregulating miR-124-3p-Upregulated the miR-124-3p by repressing DNMT1 through Sp1⇒ Amentoflavone could induce apoptosis and inhibit glycolysis in glioma cells via miR-124-3p. The gene discussed is DNMT1; the disease is central nervous system cancer.