MMP2 and cancer: -Reversed the hypermethylation status of the RECK gene-Enhanced the expression level of RECK mRNA-Inhibited the matrix metalloproteinases (MMPs) levels (MMP-2 and MMP-9) in cells-Suppressed the cancer cell-invasive ability by decreasing the number of invasive foci as well as invasion depth in three-dimensional collagen invasion model⇒ EGCG plays a key role in suppressing cell invasion through multiple mechanisms, possibly by demethylation effect on MMP inhibitors such as RECK