-Reduced HDAC and DNMT protein expression-Decreased the DNMT3B transcript in HCT 116 cells-Downregulated the DNMT transcripts in HT-29 cells-Decreased DNMT3A protein in the methylation-sensitive HCT 116 cell line in a time- and dose-dependent manner-Decreased HDAC2 and HDAC3 expression-Decreased association between UHRF1 and DNMT3 for both HCT 116 and HT-29 cell lines-Decreased association between UHRF1 and HDAC3 in only the HCT 116 cell line⇒ EGCG, in combination withother DNMT and HDAC inhibitors, could be beneficial to treat colon cancer. Here, HDAC9 is linked to malignant colon neoplasm.