SIRT1 and breast cancer: In the study reported by Kala et al. [314] on the breast cancer cell lines (MDA-MB-157, HCC1806, and MCF10A), PTS and RSV have inhibited synergistically TNBC growth, downregulated the SIRT1 and the DNMT enzymes with no significant effects on DNMT enzyme expression in MCF10A control cells.