RSV + PTS inhibited the growth of TNBCsRSV + PTS downregulated the SIRT1 (a type III HDAC)RSV + PTS decreased the γ-H2AX and telomerase expression, which resulted in significant growth inhibition, apoptosis, and cell cycle arrest in HCC1806 and MDA-MB-157 breast cancer cellsRSV + PTS downregulated the DNMT enzymes with no significant effects on DNMT enzyme expression in MCF10A control cells. Here, SIRT1 is linked to breast carcinoma.