TGFB1 and diabetic kidney disease: Yan et al. [184] explored the protective effects of naringenin on the kidney as well as its effects on let-7a/TGFBR1 signaling in diabetic nephropathy rats and mesangial cells under high glucose conditions, demonstrating that let-7a and its related pathway-TGF-β1/smad signaling formed a negative feedback to inhibit the deposition of ECM by targeting TGFBR1 in DN [184].