-Suppressed the activity and protein expression of DNMT1 and DNMT3B in HCT116, Caco-2, and SW480 cells-Demethylated the promoters of CDKN2A, and SFRP2, SFRP5, and WIF1, upstream of Wnt pathway-Increase expression of mRNA of certain genes-Decreased mRNA expression of β-catenin and c-Myc and cell proliferation-Increased apoptosis⇒ Anthocyanins are responsible, at least in part, for the demethylation effects of whole black raspberries in colorectal cancer. Here, SFRP5 is linked to colorectal cancer.