DNMT3B and cancer: Furthermore, different genes are hypermethylated in cancers such as CDKN2A, hMLH1, and APC in colorectal cancer (CRC); p16INKa, RB1, and VHL1 in renal cell carcinoma [29]; TET2, DNMT3B, IDH1, BRAF, and MYC in prostate cancer [41]; and MGMT in colon, lung, lymphoid, and other tumors [42].