-Induced the apoptosis of human leukemia HL-60 cells in a dose-dependent manner-Induced the Fas ligand (FasL) expression involving activation of the extracellular signal-regulated kinase (ERK) and Jun N-terminus kinase (JNK) signaling pathways-Increased the histone H3 acetylation which resulted in the promotion of the expression of FasL-Activated the HAT and inhibited the HDAC⇒ Quercetin induces FasL-related apoptosis by transactivation through the activation of c-jun/AP-1 and the promotion of histone H3 acetylation in HL-60 cells. This evidence concerns the gene MAPK8 and leukemia.