Another surprising discovery is that JMJD5 affects the homeostasis of both arginine-methylated histones and histone overall; depletion of JMJD5 leads to the dramatic accumulation of both components in MEF cells or human cancer cells [23], providing strong evidence to support the cleavage roles of JMJD5 on arginine-methylated histones. Here, KDM8 is linked to cancer.