AKT1 and cancer: Overall, the PI3K/AKT/mTOR axis transmits important signals that regulate a variety of physiological processes in virtually all tissue types studied to date (which have been extensively described in literature) such as proliferation, apoptosis, inflammation cellular migration and immune response, and its dysregulation is associated with development of various diseases including cancer, diabetes and autoimmunity: Here we describe highlights of the PI3K/Akt7mTORC1 axis in arteriovenous fistula patency.