Heallen and coworkers demonstrated how the shutdown of the Hippo cascade (by either in vivo SAV1 inactivation or LATS1/2 inhibition) in postnatal cardiomyocytes promoted efficient heart regeneration after cardiac apex resection and subsequent myocardial infarction (MI) in terms of cell proliferation and functional heart recovery [139]. The gene discussed is LATS1; the disease is myocardial infarction.