ERBB2 and breast cancer: Depending on the expression profile of key histological markers (i.e., oestrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2) and Ki67), BC can be classified into four main subtypes: luminal A (lumA), luminal B (lumB), triple-negative (TNBC) and HER2-related BCs [1,6].