PNPLA3 and metabolic dysfunction-associated steatotic liver disease: Targher and colleagues [17] found that in 142 children with biopsy-proven NAFLD, those with PNPLA3 GG genotype had lower eGFR (107.5 ± 20 vs. 112.8 ± 18 vs. 125.3 ± 23 mL/min/1.73 m2, p = 0.002) compared to those with CG and CC genotypes, respectively.