However, when authors tested the association between the NAFLD susceptibility gene variant and eGFR reduction in the whole cohort, NAFLD was the only factor associated with GFR reduction, thus demonstrating that fatty liver and the shared metabolic risk factors have a stronger effect on the decline of renal function than the PNPLA3 G risk allele. The gene discussed is PNPLA3; the disease is metabolic dysfunction-associated steatotic liver disease.